Chemical simulation of biogenesis of the 2, 4, 5-trihydroxyphenylalanine quinone cofactor of copper amine oxidases: Mechanistic distinctions point toward a unique …

S Mandal, Y Lee, MM Purdy…

文献索引：Gierer,J.; Imsgard,F. Acta Chemica Scandinavica, Series B: Organic Chemistry and Biochemistry, 1977 , vol. 31, p. 537 - 545

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被引用次数: 25

摘要

... J. Am. Chem. Soc. ... In addition, the failure to witness chemical precedent for the C2 hydration step of TPQ biogenesis suggests that this step must be facilitated at the enzyme active site, possibly via electrophilic activation by the active-site copper. ...