European journal of organic chemistry

Iron??Catalyzed Cross??Coupling between 1??Bromoalkynes and Grignard??Derived Organocuprate Reagents

D Castagnolo, M Botta

文献索引：Castagnolo, Daniele; Botta, Maurizio European Journal of Organic Chemistry, 2010 , # 17 p. 3224 - 3228

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被引用次数: 16

摘要

Abstract An efficient iron-catalyzed cross-coupling reaction between alkynyl bromides and Grignard-derived organocuprates has been developed. A series of alkynylarenes were successfully synthesised by starting from different 1-bromoalkynes and Grignard reagents. The methodology was successfully used for the two-step stereoselective synthesis of combretastatins and represents a valid alternative to the classical syntheses of ...