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Prostaglandins and congeners. 28. Synthesis of 2-(. omega.-carbalkoxyalkyl) cyclopent-2-en-1-ones, intermediates for prostaglandin syntheses

KF Bernady, JF Poletto, J Nocera…

文献索引:Bernady; Poletto; Nocera; et al. Journal of Organic Chemistry, 1980 , vol. 45, # 23 p. 4702 - 4715

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被引用次数: 34

摘要

A methodology is described for the synthesis of the 2-substituted cyclopentenone precursors required for the preparation of 11-deoxyprostaglands by the conjugate addition pmedure. Among the cyclopentenones so prepared were some with features designed to inhibit or prevent fatty acid P-oxidative metabolism of the ultimate prostaglandin analogue. These features include methyl, ethyl, phenyl, and fluorine substituents at the a position of the fatty ...

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