A methodology is described for the synthesis of the 2-substituted cyclopentenone precursors required for the preparation of 11-deoxyprostaglands by the conjugate addition pmedure. Among the cyclopentenones so prepared were some with features designed to inhibit or prevent fatty acid P-oxidative metabolism of the ultimate prostaglandin analogue. These features include methyl, ethyl, phenyl, and fluorine substituents at the a position of the fatty ...