Catalytic racemisation of chiral amines and application in dynamic kinetic resolution

AJ Blacker, MJ Stirling, MI Page

文献索引：Blacker, A. John; Stirling, Matthew J.; Page, Michael I. Organic Process Research and Development, 2007 , vol. 11, # 3 p. 642 - 648

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被引用次数: 81

摘要

A mild and efficient procedure for the racemisation of optically active amines has been developed and applied to the dynamic kinetic resolution (DKR) of a racemic amine. Pentamethylcyclopentadienyliridium (III) iodide dimer dissolved in a convenient solvent is the precatalyst that reacts in situ with primary, secondary, or tertiary amines to form what we have named a SCRAM catalyst. This is able to dehydrogenate a substrate amine to form ...