Reductive amination of aromatic aldehydes and ketones with nickel boride

I Saxena, R Borah, JC Sarma

文献索引：Saxena, Ira; Borah, Ruli; Sarma, Jadab C. Journal of the Chemical Society, Perkin Transactions 1, 2000 , # 4 p. 503 - 504

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被引用次数: 59

摘要

Although several reagents are available for reductive amination most of the reagents have one drawback or another. Hydrogenation is not compatible with compounds that contain a double or a triple bond and several other reducible functional groups. Sodium cyanoborohydride requires up to a 5 fold excess of the amine and may result in the contamination of the product with cyanide. Moreover, this reagent is highly toxic and generates toxic byproducts HCN and ...