Research on Chemical Intermediates

I2/TBHP-mediated domino process: a convenient route to 1, 3-oxazole derivatives

CT Feng, M Zhao, ST Ma, X Qin

文献索引：Feng, Cheng-Tao; Zhao, Ming; Ma, Shi-Tang; Qin, Xia Research on Chemical Intermediates, 2013 , vol. 39, # 8 p. 3835 - 3841

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被引用次数: 0

摘要

Abstract A practical and simple synthesis of 2, 5-disubstituted oxazoles was developed via a TBHP (tert-butyl hydroperoxide)/I 2-mediated domino strategy. The reaction proceeds in series, giving rise to the formation of an intermolecular C–N bond and an intramolecular C– O bond, which yield oxazole derivatives simultaneously. The reaction gave the desired products from readily available substrates under mild conditions.