Inflammatory mediators such as histamine, leukotrienes, prostaglandins, proteases, and chemotactic factors released by various cells are responsible for the symptoms of allergic diseases.'Thus, inhibition of mediator release has been an attractive approach for the development of antiallergic drugs. Historically, the passive cutaneous anaphylaxis (PCA) model in the rat has been the primary allergic model for characterizing mast cell stabilizers ...
