Macrocyclic polyamines deplete cellular ATP levels and inhibit cell growth in human prostate cancer cells

…, S Bhattacharya, A Sarkar, K Drandarov…

文献索引：Frydman, Benjamin; Bhattacharya, Subhra; Sarkar, Aparajita; Drandarov, Konstantin; Chesnov, Sergiy; Guggisberg, Armin; Popaj, Kasim; Sergeyev, Sergey; Yurdakul, Aysil; Hesse, Manfred; Basu, Hirak S.; Marton, Laurence J. Journal of Medicinal Chemistry, 2004 , vol. 47, # 4 p. 1051 - 1059

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被引用次数: 38

摘要

In solid tumors, when O2 partial pressure drops below 10 mmHg, ATP levels rapidly decrease due to the Warburg effect. It is known that certain macrocyclic polyamines catalyze the chemical hydrolysis of ATP with release of inorganic phosphate. Since tumor cells have diminished ATP levels as compared to normal cells, we attempted to deplete cellular ATP with macrocyclic polyamines in an effort to inhibit tumor cell proliferation. Five macrocyclic ...