Tetrahedron Letters

Carbonyl reduction with CaH 2 and R 3 SiCl catalyzed by ZnCl 2

A Tsuhako, JQ He, M Mihara, N Saino, S Okamoto

文献索引：Tsuhako, Akiko; He, Jing-Qian; Mihara, Mariko; Saino, Naoko; Okamoto, Sentaro Tetrahedron Letters, 2007 , vol. 48, # 52 p. 9120 - 9123

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被引用次数: 10

摘要

Ketones and aldehydes were effectively reduced to the corresponding alcohols (or their silyl ethers) by the reaction with CaH2 and R3SiCl in the presence of a catalytic amount of ZnCl2. In the absence of the carbonyl substrate, the reagent reduced R3SiCl to the corresponding hydrosilane under mild reaction conditions.