前往化源商城

Switchable Reactivity: The Site??Selective Functionalization of Trifluoromethyl??Substituted Pyrazoles

M Schlosser, JN Volle, F Leroux…

文献索引:Schlosser, Manfred; Volle, Jean-Noel; Leroux, Frederic; Schenk, Kurt European Journal of Organic Chemistry, 2002 , # 17 p. 2913 - 2920

全文:HTML全文

被引用次数: 39

摘要

Abstract Modern organometallic methods enable the regioflexible conversion of simple heterocyclic starting materials into families of isomers and congeners. Depending on the choice of the reagent, 1-methyl-5-(trifluoromethyl) pyrazole (1) undergoes deprotonation and subsequent carboxylation mainly or exclusively at either the 4-position of the heterocycle or at the nitrogen-attached methyl group. Similarly, 1-phenyl-5-(trifluoromethyl) pyrazole (5) ...

 相关合成线路

~60%

~85%

~71%

~93%

~67%

~5%

~%

~%

~64%

~66%

~%

~88%

~%

~80%

~13%

~%

~%

~48%

~78%

~25%