Pyridazinones. 3. Synthesis, antisecretory, and antiulcer activities of 2-cyanoguanidine derivatives

T Yamada, H Shimamura, Y Tsukamoto…

文献索引：Yamada, Toshihiro; Shimamura, Hiroshi; Tsukamoto, Yoshitsugu; Yamaguchi, Azuma; Ohki, Masahiko Journal of Medicinal Chemistry, 1983 , vol. 26, # 8 p. 1144 - 1149

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被引用次数: 23

摘要

3 (W)-Ppidazinone derivatives having a 2-cyanoguanidine moiety, as well as a sulfur or an oxygen atom in the alkylene side chain, were synthesized and evaluated for gastric antisecretory and antiulcer activities. The key intermediates, free amines having a thioether linkage, were synthesized by the reaction of 2-(w-chl0r0alkyl) derivatives with cysteamine, while other intermediates having an ether linkage were synthesized from 2-(w-chloroalkyl) ...