3 (W)-Ppidazinone derivatives having a 2-cyanoguanidine moiety, as well as a sulfur or an oxygen atom in the alkylene side chain, were synthesized and evaluated for gastric antisecretory and antiulcer activities. The key intermediates, free amines having a thioether linkage, were synthesized by the reaction of 2-(w-chl0r0alkyl) derivatives with cysteamine, while other intermediates having an ether linkage were synthesized from 2-(w-chloroalkyl) ...
