… formation in DNA by the radicals released in the photolysis of N-tert-butoxy-2-pyridone. Are tert-butoxyl or methyl radicals responsible for the photooxidative damage …

…, S Marquardt, D Kemmer, CR Saha-Möller…

文献索引：Adam, Waldemar; Marquardt, Stefan; Kemmer, Diana; Saha-Moller, Chantu R.; Schreier, Peter Organic Letters, 2002 , vol. 4, # 2 p. 225 - 228

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被引用次数: 15

摘要

The photolysis of pyridone 3b (photo-Fenton reagent) in benzene releases tert-butoxyl radicals, which have been trapped by DMPO and EPR-spectrally identified. In aqueous solution, however, the fragmentation of the tert-butoxyl into methyl radicals prevails and the former radicals are of no direct consequence in the photooxidation of 2'-deoxyguanosine (dG) and pBR 322 DNA. The photooxidative damage of nucleic acids is caused by the ...