Hydroxy derivatives of tamoxifen

…, G Leclercq, N Devleeschouwer

文献索引：Foster; Jarman; Leung; McCague; Leclercq; Devleeschouwer Journal of Medicinal Chemistry, 1985 , vol. 28, # 10 p. 1491 - 1497

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被引用次数: 109

摘要

1492 Journal of Medicinal Chemistry, 1985, Vol. 28, No. 10 question7 of the role of this metabolite in the expression of the biological activity of tamoxifen (1). As expected from the RBA values, 4-hydroxytamoxifen (5) is more effective than tamoxifen (1) in inhibiting the growth of the ER-positive MCF-7 breast cancer cell line. 4, 8 However, the in vivo antitumor activity of 5 does not reflect the high RBA since it was less activeg than tamoxifen (1) ...