Benzo [b] thiophene Derivatives. IV. 1 The Preparation and Pharmacological Activity of Compounds Related to Serotonin and Gramine

JJ Lewis, M Martin-Smith, TC Muir…

文献索引：Lewis,J.J. et al. Journal of Medicinal Chemistry, 1963 , vol. 6, p. 711 - 716

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被引用次数: 6

摘要

A number of derivatives of benzo [b] thiophene related to serotonin and gramine have been prepared and tested for pharmacological activity on a variety of smooth muscle preparations and on intact animals. Antihistamine, antiacetylcholine, antiserotonin, and in some cases spasmogenic properties have been demonstrated. The replacement of the indole ring system by the benzo [b] thiophene system in the compounds studied leads to a reduction ...