Benzamidobenzoic acids as potent PqsD inhibitors for the treatment of Pseudomonas aeruginosa infections
…, M Groh, J Haupenthal, RW Hartmann
文献索引：Hinsberger, Stefan; De Jong, Johannes C.; Groh, Matthias; Haupenthal, Joerg; Hartmann, Rolf W. European Journal of Medicinal Chemistry, 2014 , vol. 76, p. 343 - 351
Abstract Targeting PqsD is a promising novel approach to disrupt bacterial cell-to-cell- communication in Pseudomonas aeruginosa. In search of selective PqsD inhibitors, two series of benzamidobenzoic acids–one published as RNAP inhibitors and the other as PqsD inhibitors–were investigated for inhibitory activity toward the respective other enzyme. Additionally, novel derivatives were synthesized and biologically evaluated. By this means ...
