Benzamidobenzoic acids as potent PqsD inhibitors for the treatment of Pseudomonas aeruginosa infections

…, M Groh, J Haupenthal, RW Hartmann

Index: Hinsberger, Stefan; De Jong, Johannes C.; Groh, Matthias; Haupenthal, Joerg; Hartmann, Rolf W. European Journal of Medicinal Chemistry, 2014 , vol. 76, p. 343 - 351

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Citation Number: 11

Abstract

Abstract Targeting PqsD is a promising novel approach to disrupt bacterial cell-to-cell- communication in Pseudomonas aeruginosa. In search of selective PqsD inhibitors, two series of benzamidobenzoic acids–one published as RNAP inhibitors and the other as PqsD inhibitors–were investigated for inhibitory activity toward the respective other enzyme. Additionally, novel derivatives were synthesized and biologically evaluated. By this means ...