Routine screening of compounds for inhibition of collagen-induced platelet aggregation in vitro revealed 4, 5-bis-(4-methoxyphenyl)-l, 2, 3-thiadiazole (2) was active and it represents the first example of a 1, 2, 3-thiadiazole with possible antithrombotic activity. In order to devleop a structure-activity relationship for this heterocycle, a number of new 4 (5)-mono- and-disubstituted 1, 2, 34hiadiazoles were synthesized. These were tested in our screen ...
