1-(Phenyl) isoquinoline carboxamides: a novel class of subtype selective inhibitors of thyrotropin-releasing hormone (TRH) receptors

J Jiang, CJ Thomas, S Neumann, X Lu, KC Rice…

文献索引：Jiang, Jian-Kang; Thomas, Craig J.; Neumann, Susanne; Lu, Xinping; Rice, Kenner C.; Gershengorn, Marvin C. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 3 p. 733 - 736

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被引用次数: 8

摘要

We report the synthesis of and binding to the two subtypes of mouse thyrotropin-releasing hormone (TRH) receptors, TRH-R1 and TRH-R2, of several 1-(phenyl) isoquinoline carboxamide analogues. These analogues showed a degree of selectivity for binding at TRH-R2. These are the first ligands reported that show selective binding to these receptors.