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举例 :可输入Filippa Pettersson 或者 Cancer Res. 75(6) , 1102-12, (2015) 或者10.1002/anie.201600521

Synthetic approaches to 1-(2-chlorophenyl) isoquinoline-3-carboxylic acid

YL Janin, E Roulland, A Beurdeley-Thomas…

文献索引：Janin, Yves L.; Roulland, Emmanuel; Beurdeley-Thomas, Arnaud; Decaudin, Didier; Monneret, Claude; Poupon, Marie-France Journal of the Chemical Society. Perkin Transactions 1, 2002 , # 4 p. 529 - 532

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被引用次数: 9

摘要

In connection with our research of new antitumor compounds, previously undescribed approaches to the 1-(2-chlorophenyl) isoquinoline-3-carboxylic acid 9 are reported here. Two related accesses from phenylethylamine or amphetamine were investigated and were found to be successful. A more robust synthesis, using Suzuki's cross-coupling between 2- chlorophenylboronic acid 15 and the previously unreported methyl-1-bromoisoquinoline-3 ...

邻氯苯甲酰氯结构式

邻氯苯甲酰氯

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1-(2-氯-苯基)-3,4-二氢-异喹啉结构式

1-(2-氯-苯基)-3,4-...

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β-苯乙胺结构式

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1-(2-氯-苯基)-3,4-二氢-异喹啉结构式

1-(2-氯-苯基)-3,4-...

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甲醇结构式

1-oxo-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid(SALTDATA: FREE)结构式

1-oxo-1,2,3,4-t...

~90%

Methyl 1-hydroxy-3,4-dihydro-3-isoquinolinecarboxylate结构式

Methyl 1-hydrox...

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1-oxo-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid(SALTDATA: FREE)结构式

1-oxo-1,2,3,4-t...

~%

1-溴异喹啉-3-羧酸甲酯结构式

1-溴异喹啉-3-羧酸甲酯

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Methyl 1-hydroxy-3,4-dihydro-3-isoquinolinecarboxylate结构式

Methyl 1-hydrox...

~%

1-溴异喹啉-3-羧酸甲酯结构式

1-溴异喹啉-3-羧酸甲酯

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未登录结构式

~63%

1-(2-chlorophenyl)-3-methylisoquinoline结构式

1-(2-chlorophen...

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N-(β-phenyl)isopropyl-o-chlorobenzamide结构式

N-(β-phenyl)iso...

~%

1-(2-chlorophenyl)-3-methylisoquinoline结构式

1-(2-chlorophen...

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1-苯基-2-丙胺结构式

1-苯基-2-丙胺

~%

1-(2-chlorophenyl)-3-methylisoquinoline结构式

1-(2-chlorophen...

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2-氯苯基硼酸结构式

2-氯苯基硼酸

1-溴异喹啉-3-羧酸甲酯结构式

1-溴异喹啉-3-羧酸甲酯

~0%

邻氯苯酚结构式

1-(2-chlorophenyl)isoquinoline-3-carboxylic acid methyl ester结构式

1-(2-chlorophen...

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1-oxo-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid(SALTDATA: FREE)结构式

1-oxo-1,2,3,4-t...

~%

1-氯异喹啉-3-羧酸甲酯结构式

1-氯异喹啉-3-羧酸甲酯

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Methyl 1-hydroxy-3,4-dihydro-3-isoquinolinecarboxylate结构式

Methyl 1-hydrox...

~%

1-氯异喹啉-3-羧酸甲酯结构式

1-氯异喹啉-3-羧酸甲酯

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1-(2-chlorophenyl)isoquinoline-3-carbaldehyde结构式

1-(2-chlorophen...

~83%

1-(2-chlorophenyl)isoquinoline-3-carboxylic acid结构式

1-(2-chlorophen...

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1-氧代-1,2-二氢异喹啉-3-羧酸甲酯结构式

1-氧代-1,2-二氢异喹啉-...

~%

1-(2-chlorophenyl)isoquinoline-3-carboxylic acid结构式

1-(2-chlorophen...

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1-oxo-1,2,3,4-tetrahydro-3-isoquinolinecarboxylic acid(SALTDATA: FREE)结构式

1-oxo-1,2,3,4-t...

~%

1-(2-chlorophenyl)isoquinoline-3-carboxylic acid结构式

1-(2-chlorophen...

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Methyl 1-hydroxy-3,4-dihydro-3-isoquinolinecarboxylate结构式

Methyl 1-hydrox...

~%

1-(2-chlorophenyl)isoquinoline-3-carboxylic acid结构式

1-(2-chlorophen...

查看详情

1-溴异喹啉-3-羧酸甲酯结构式

1-溴异喹啉-3-羧酸甲酯

~%

1-(2-chlorophenyl)isoquinoline-3-carboxylic acid结构式

1-(2-chlorophen...

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未登录结构式

~%

1-(2-chlorophenyl)isoquinoline-3-carboxylic acid结构式

1-(2-chlorophen...

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N-(β-phenyl)isopropyl-o-chlorobenzamide结构式

N-(β-phenyl)iso...

~%

1-(2-chlorophenyl)isoquinoline-3-carboxylic acid结构式

1-(2-chlorophen...

查看详情

1-苯基-2-丙胺结构式

1-苯基-2-丙胺

~%

1-(2-chlorophenyl)isoquinoline-3-carboxylic acid结构式

1-(2-chlorophen...

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1-(2-chlorophenyl)-3-hydroxymethylisoquinoline结构式

1-(2-chlorophen...

~%

1-(2-chlorophenyl)isoquinoline-3-carboxylic acid结构式

1-(2-chlorophen...

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未登录结构式

~%

1-(2-chlorophenyl)isoquinoline-3-carboxylic acid结构式

1-(2-chlorophen...

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1-(2-氯-苯基)-3,4-二氢-异喹啉结构式

1-(2-氯-苯基)-3,4-...

~69%

1-(2-氯-苯基)-异喹啉结构式

1-(2-氯-苯基)-异喹啉

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2-CHLORO-N-PHENETHYL-BENZAMIDE结构式

2-CHLORO-N-PHEN...

~%

1-(2-氯-苯基)-异喹啉结构式

1-(2-氯-苯基)-异喹啉

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邻氯苯甲酰氯结构式

邻氯苯甲酰氯

~%

1-(2-氯-苯基)-异喹啉结构式

1-(2-氯-苯基)-异喹啉

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β-苯乙胺结构式

~%

1-(2-氯-苯基)-异喹啉结构式

1-(2-氯-苯基)-异喹啉

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Mild and Efficient Syntheses of 1-Aryl-3, 4-dihydroisoquinol...

[Dong, Jing; Shi, Xiao-Xin; Xing, Jing; Yan, Jing-Jing Synthetic Communications, 2012 , vol. 42, # 19 p. 2806 - 2817]