Organic letters

Diels− Alder Cycloaddition Strategy for Kinetic Resolution of Chiral Pyrazolidinones

MP Sibi, K Kawashima, LM Stanley

文献索引：Sibi, Mukund P.; Kawashima, Keisuke; Stanley, Levi M. Organic Letters, 2009 , vol. 11, # 17 p. 3894 - 3897

全文：HTML全文

被引用次数: 19

摘要

A rare example of the application of a catalytic, enantioselective Diels− Alder cycloaddition to affect a kinetic resolution has been developed. Chiral pyrazolidinones are resolved with high selectivity through a process that utilizes a relay of stereochemical information from a permanent chiral center to a fluxional chiral center to enhance the inherent selectivity of the chiral Lewis acid catalyst.