A regioselective synthesis of 2, 4, 6-trisubstituted pyridine is described starting from 2, 6- dibromo-4-nitropyridine. All three different regioisomers of the 2, 4, 6-triamino substituted pyridine have been synthesized in four to five steps. The method described is a general route to unsymmetrical 2, 4, 6-trisubstituted amino pyridines.