Regioselective synthesis of 2, 4, 6-triaminopyridines

…, D Nguyen, D Flubacher, F Ruggle, A Schumacher…

Index: Shetty, Rupa; Nguyen, Duyan; Flubacher, Dietmar; Ruggle, Franziska; Schumacher, Andreas; Kelly, Martha; Michelotti, Enrique Tetrahedron Letters, 2007 , vol. 48, # 1 p. 113 - 117

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Citation Number: 3

Abstract

A regioselective synthesis of 2, 4, 6-trisubstituted pyridine is described starting from 2, 6- dibromo-4-nitropyridine. All three different regioisomers of the 2, 4, 6-triamino substituted pyridine have been synthesized in four to five steps. The method described is a general route to unsymmetrical 2, 4, 6-trisubstituted amino pyridines.