Tetrahedron

Enantioselective microbial hydrolysis of dissymmetrical cyclic carbonates with disubstitution

M Nogawa, S Sugawara, R Iizuka, M Shimojo, H Ohta…

文献索引：Nogawa, Masaki; Sugawara, Satomi; Iizuka, Rie; Shimojo, Megumi; Ohta, Hiromichi; Hatanaka, Minoru; Matsumoto, Kazutsugu Tetrahedron, 2006 , vol. 62, # 51 p. 12071 - 12083

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被引用次数: 13

摘要

Enantioselective microbial hydrolysis of C1 and C2 dissymmetrical cyclic carbonates with disubstitution (methyl and another groups) has been developed. Pseudomonas diminuta (FU0090), a bacterium, efficiently catalyzes the hydrolysis of five-membered cyclic carbonates. While the trans-substrates are hydrolyzed with low enantioselectivities and/or reactivities, the microbe hydrolyzes the cis-substrates with very high enantioselectivities to ...