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Total synthesis and biological evaluation of viscolin, a 1, 3-diphenylpropane as a novel potent anti-inflammatory agent

…, PC Kuo, YL Leu, AG Damu, YH Wang, TS Wu

文献索引：Su, Chung-Ren; Shen, Yuh-Chiang; Kuo, Ping-Chung; Leu, Yann-Lii; Damu, Amooru G.; Wang, Yea-Hwey; Wu, Tian-Shung Bioorganic and Medicinal Chemistry Letters, 2006 , vol. 16, # 24 p. 6155 - 6160

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被引用次数: 26

摘要

Total synthesis of viscolin, an anti-inflammatory 1, 3-diphenylpropane isolated from Viscum coloratum, employing the Wittig reaction is reported. Key steps in the synthesis of viscolin depend on the selection of protecting groups to maintain the para hydroxyl group that is the most critical chemical structure influencing the biological activity of viscolin and the utilization of microwave-assisted Wittig olefination reaction. Anti-inflammatory potency of ...

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