The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3 (4H)-yl] benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the …
DS Brown, JG Cumming, P Bethel, J Finlayson…
文献索引：Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 12 p. 3879 - 3883
... Bioorganic & Medicinal Chemistry Letters. ... Disappointingly however, although a number of compounds from diverse chemical series have progressed into clinical trials none has yet demonstrated that inhibition of p38α can deliver a safe and efficacious treatment of ...
