The discovery of N-cyclopropyl-4-methyl-3-[6-(4-methylpiperazin-1-yl)-4-oxoquinazolin-3 (4H)-yl] benzamide (AZD6703), a clinical p38α MAP kinase inhibitor for the …

DS Brown, JG Cumming, P Bethel, J Finlayson…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 12 p. 3879 - 3883

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Citation Number: 4

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... Disappointingly however, although a number of compounds from diverse chemical series have progressed into clinical trials none has yet demonstrated that inhibition of p38α can deliver a safe and efficacious treatment of ...