Synthesis and anti-filarial activity of 6-(3-aminophenyl)-2, 3, 5, 6-tetrahydroimidazol [2, 1-b] thiazole derivatives

JCW Comley, JP Court, WE Gutteridge…

文献索引：Comely, JCW; Court, JP; Gutteridge, WE; Hudson, AT; Jenkins, DC; et al. European Journal of Medicinal Chemistry, 1992 , vol. 27, # 5 p. 503 - 509

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被引用次数: 4

摘要

Abstract Structure activity studies against filariae are described for a series of derivatives of 6- (3-aminophenyl)-2, 3, 5, 6-tetrahydroimidazo [2, 1-b] thiazole (15 derivatives. In an in vivo assay using gerbils implanted with both Acanthocheilonema viteae and Brugia pahangi, the former parasite was shown to be the more sensitive to a range of amides of 15. None of these compounds, however, had any activity at 5× 10− 5 mol against the worms in vitro ...