Abstract Structure activity studies against filariae are described for a series of derivatives of 6- (3-aminophenyl)-2, 3, 5, 6-tetrahydroimidazo [2, 1-b] thiazole (15 derivatives. In an in vivo assay using gerbils implanted with both Acanthocheilonema viteae and Brugia pahangi, the former parasite was shown to be the more sensitive to a range of amides of 15. None of these compounds, however, had any activity at 5× 10− 5 mol against the worms in vitro ...
![d-6-(m-aminophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b]thiazole dihydrochloride Structure](https://image.chemsrc.com/caspic/474/37142-98-6.png)
![N-[3-(2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazol-6-yl)phenyl]benzamide Structure](https://image.chemsrc.com/caspic/343/39842-26-7.png)