2-Aryl benzimidazoles featuring alkyl-linked pendant alcohols and amines as inhibitors of checkpoint kinase Chk2

…, A Lee-Dutra, JM Blevitt, FU Axe, MD Hack…

文献索引：Neff, Danielle K.; Lee-Dutra, Alice; Blevitt, Jonathan M.; Axe, Frank U.; Hack, Michael D.; Buma, Johnathan C.; Rynberg, Raymond; Brunmark, Anders; Karlsson, Lars; Breitenbucher, J. Guy Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 23 p. 6467 - 6471

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被引用次数: 26

摘要

A series of benzimidazole compounds containing pendant alcohol and amine moieties was found to be active against checkpoint kinase Chk2. These compounds were prepared to examine a potential hydrogen bond interaction with an active site residue and to investigate replacement of a biaryl linker with an aliphatic system in an effort to improve solubility.