Lead identification of acetylcholinesterase inhibitors–histamine H 3 receptor antagonists from molecular modeling

…, R Apodaca, AJ Barbier, L Dvorak, L Aluisio…

文献索引：Bembenek, Scott D.; Keith, John M.; Letavic, Michael A.; Apodaca, Richard; Barbier, Ann J.; Dvorak, Lisa; Aluisio, Leah; Miller, Kirsten L.; Lovenberg, Timothy W.; Carruthers, Nicholas I. Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 6 p. 2968 - 2973

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被引用次数: 57

摘要

Currently, the only clinically effective treatment for Alzheimer's disease (AD) is the use of acetylcholinesterase (AChE) inhibitors. These inhibitors have limited efficacy in that they only treat the symptoms and not the disease itself. Additionally, they often have unpleasant side effects. Here we consider the viability of a single molecule having the actions of both an AChE inhibitor and histamine H3 receptor antagonist. Both histamine H3 receptor ...