Molecular size and flexibility as determinants of selectivity in the oxidation of N-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine analogs by monoamine oxidase A and B

SMN Efange, RH Michelson, AK Tan…

文献索引：Efange, S. M. N.; Michelson, R. H.; Tan, A. K.; Krueger, M. J.; Singer, T. P. Journal of Medicinal Chemistry, 1993 , vol. 36, # 9 p. 1278 - 1283

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被引用次数: 16

摘要

The introduction of a methylene bridge between the phenyl and tetrahydropyridyl moieties of l-methyl-4phenyl-l, 2, 3, 6-tetrahydropyridine (MPTP) results in increased selectivity for monoamine oxidase B (MA0 B) over monoamine oxidase A (MA0 A). However, lengthening of this bridge results in a total loss of selectivity, In the present study, a number of isomeric 4- naphthyl-, 4-(naphthylalky1)-, 4-thienyl-, and 4-(thienylalkyl) tetrahydropyridines, ...