Synthesis and monoamine oxidase B catalyzed oxidation of C-4 heteroaromatic substituted 1, 2, 3, 6-tetrahydropyridine derivatives

…, JM Rimoldi, M Stanton, KP Castagnoli…

文献索引：Nimkar, Sandeep K.; Anderson, Andrea H.; Rimoldi, John M.; Stanton, Matthew; Castagnoli, Kay P.; Mabic, Stephane; Wang; Castagnoli Jr., Neal Chemical Research in Toxicology, 1996 , vol. 9, # 6 p. 1013 - 1022

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被引用次数: 31

摘要

The monoamine oxidase B (MAO-B) catalyzed oxidation of amines has been proposed to proceed via a polar pathway, an initial single-electron transfer pathway and an initial hydrogen atom transfer pathway. Results from previous studies on selected N-cyclopropyl-4- substituted-1, 2, 3, 6-tetrahydropyridine derivatives have led us to consider a mechanism for these cyclic tertiary allylamines which may not necessarily involve the aminyl radical ...