Efficient one-step synthesis of trialkylsubstituted 2 (5H)-furanones utilizing direct Ti-crossed aldol condensation and its application to the straightforward synthesis of ( …
Y Tanabe, K Mitarai, T Higashi, T Misaki…
文献索引：Tanabe, Yoo; Mitarai, Kumi; Higashi, Takahiro; Misaki, Tomonori; Nishii, Yoshinori Chemical Communications, 2002 , # 21 p. 2542 - 2543
TiCl4–Bu3N-mediated condensation of ketones with α, α-dimethoxyketones afforded trialkylsubstituted 2 (5H)-furanones in a one-pot manner, wherein aldol addition and furanone formation occurred sequentially; its application to straightforward synthesis of (R)- mintlactone and (R)-menthofuran, two representative natural mint perfumes, is demonstrated.
