Journal of the American Chemical Society

Synthesis of lactones by the palladium-catalyzed carbonylation of halo alcohols

A Cowell, JK Stille

文献索引：Cowell,A.; Stille,J.K. Journal of the American Chemical Society, 1980 , vol. 102, p. 4193

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被引用次数: 195

摘要

Abstract: The synthesis of lactones in high yields by the palladium-catalyzed carbonylation reaction of halo alcohols can be effected under mild conditions (1-4 atm CO, 25-60" C) with a high turnover of palladium. Benzyl, allyl, aryl, and vinyl halides containing primary, secondary, or tertiary alcohol groups are readily converted to a variety of lactones, including phthalides and butenolides, by this simple procedure.