Synthesis and Immunosuppressive Activity of 2-Substituted 2-Aminopropane-1, 3-diols and 2-Aminoethanols 1, 2

…, Y Hoshino, K Teshima, K Chiba, S Sasaki…

文献索引：Kiuchi, Masatoshi; Adachi, Kunitomo; Kohara, Toshiyuki; Minoguchi, Masanori; Hanano, Tokushi; Aoki, Yoshiyuki; Mishina, Tadashi; Arita, Masafumi; Nakao, Noriyoshi; Ohtsuki, Makio; Hoshino, Yukio; Teshima, Koji; Chiba, Kenji; Sasaki, Shigeo; Fujita, Tetsuro Journal of Medicinal Chemistry, 2000 , vol. 43, # 15 p. 2946 - 2961

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被引用次数: 244

摘要

A series of 2-substituted 2-aminopropane-1, 3-diols was synthesized and evaluated for their lymphocyte-decreasing effect and immunosuppressive effect on rat skin allograft. A phenyl ring was introduced into the alkyl chain of the lead compound 3, which is an immunosuppressive agent structurally simplified from myriocin (1, ISP-I) via compound 2. The potency of the various compounds was dependent upon the position of the phenyl ...