Benzophenone-containing fatty acids and their related photosensitive fluorescent new probes: Design, physico-chemical properties and preliminary functional …

…, SL Niu, B Frisch, EI Pécheur, L Bourel-Bonnet

文献索引：Hilbold, Benoit; Perrault, Marie; Ehret, Christophe; Niu, Song-Lin; Frisch, Benoit; Pecheur, Eve-Isabelle; Bourel-Bonnet, Line Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 24 p. 7464 - 7473

全文：HTML全文

被引用次数: 2

摘要

Hydrophobic photoaffinity labeling is a powerful strategy to identify hydrophobic segments within molecules, in particular membrane proteins. Here we report the design and synthesis of a novel family of fluorescent and photosensitive lipid tools, which have a common amino acid scaffold functionalized by three groups:(i) a first fatty acid chain grafted with a photoactivatable benzophenone moiety (Fatty Acid BenzoPhenone, FABP),(ii) a second ...