Tetrahedron Letters

(Chloro-phenylthio-methylene) dimethylammonium chloride (CPMA) an efficient reagent for selective chlorination and bromination of primary alcohols

L Gomez, F Gellibert, A Wagner, C Mioskowski

文献索引：Gomez; Gellibert; Wagner; Mioskowski Tetrahedron Letters, 2000 , vol. 41, # 32 p. 6049 - 6052

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被引用次数: 30

摘要

(Chloro-phenylthio-methylene) dimethylammonium chloride reacts smoothly with a variety of alcohols, to afford the corresponding alkyl chloride in good yields. In the presence of tetrabuthylammonium bromide the corresponding bromide is obtained. Selective halogenation of primary hydroxyl groups in the presence of an unprotected secondary one is described. The mild reaction conditions involved are compatible with the major alcohol ...