Developing new isotope-coded mass spectrometry-cleavable cross-linkers for elucidating protein structures

…, W Kandur, A Kao, S Rychnovsky, L Huang

文献索引：Yu, Clinton; Kandur, Wynne; Kao, Athit; Rychnovsky, Scott; Huang, Lan Analytical Chemistry, 2014 , vol. 86, # 4 p. 2099 - 2106

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被引用次数: 9

摘要

Structural characterization of protein complexes is essential for the understanding of their function and regulation. However, it remains challenging due to limitations in existing tools. With recent technological improvements, cross-linking mass spectrometry (XL-MS) has become a powerful strategy to define protein–protein interactions and elucidate structural topologies of protein complexes. To further advance XL-MS studies, we present here the ...