Fluorinated 9H-xanthene-9-carboxylic acid oxazol-2-yl-amides as potent, orally available mGlu1 receptor enhancers

…, S Jolidon, F Knoflach, V Mutel, J Wichmann

文献索引：Vieira, Eric; Huwyler, Joerg; Jolidon, Synese; Knoflach, Frederic; Mutel, Vincent; Wichmann, Juergen Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 6 p. 1666 - 1669

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被引用次数: 29

摘要

Small molecule mGluR1 enhancers, which are 9H-xanthene-9-carboxylic acid [1, 2, 4] oxadiazol-3-yl-and (2H-tetrazol-5-yl)-amides, have been previously reported. Fluorinated 9H- xanthene-9-carboxylic acid oxazol-2-yl-amides with improved pharmacokinetic properties have been designed and synthesized as useful pharmacological tools for the study of the physiological roles mediated by mGlu1 receptors. The synthesis and the structure–activity ...