Intercalating agents with covalent bond forming capability. A novel type of potential anticancer agents. 2. Derivatives of chrysophanol and emodin

…, TC Chou, Z Darzynkiewicz, J Kapuscinski…

文献索引：Koyama; Takahashi; Chou; Darzynkiewicz; Kapuscinski; Kelly; Watanabe Journal of Medicinal Chemistry, 1989 , vol. 32, # 7 p. 1594 - 1599

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被引用次数: 92

摘要

Fifty-one new C-methyl-modified derivatives of the anthraquinones chrysophanol and emodin or their various methyl ethers were prepared for structure-activity relationship studies of anticancer activity against mouse leukemia L1210 and human leukemia HL-60 cells. Representative compounds were spectrophotometrically studied for their capacity to interact with natural and denatured DNA. In general, those anthraquinones bearing an ...