Natural product reports

Anticancer drugs from nature—natural products as a unique source of new microtubule-stabilizing agents

KH Altmann, J Gertsch

文献索引：Kabaki; Inoue; Sato Synthetic Communications, 1992 , vol. 22, # 3 p. 459 - 466

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被引用次数: 217

摘要

... 22,23 In addition, a number of other natural products have been reported to exhibit ... received first FDA approval (as Taxol®) for the treatment of metastatic ovarian cancer in 1992. ... tree (T. baccata); elaboration of this precursor into taxol involves reaction with a synthetic β-lactam ...