A library approach to the development of BenzaPhos: highly efficient chiral supramolecular ligands for asymmetric hydrogenation

L Pignataro, C Bovio, M Civera…

文献索引：Pignataro, Luca; Bovio, Chiara; Civera, Monica; Piarulli, Umberto; Gennari, Cesare Chemistry - A European Journal, 2012 , vol. 18, # 33 p. 10368 - 10381

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被引用次数: 22

摘要

Abstract A library of chiral supramolecular ligands, named BenzaPhos, of straightforward preparation (two steps from commercially or readily available starting materials) and modular structure, was designed and synthesized. The ligands were screened in the search for new rhodium catalysts for the enantioselective hydrogenation of several benchmark and industrially relevant substrates. Once a series of hits were identified, structural ...