A library approach to the development of BenzaPhos: highly efficient chiral supramolecular ligands for asymmetric hydrogenation

L Pignataro, C Bovio, M Civera…

Index: Pignataro, Luca; Bovio, Chiara; Civera, Monica; Piarulli, Umberto; Gennari, Cesare Chemistry - A European Journal, 2012 , vol. 18, # 33 p. 10368 - 10381

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Citation Number: 22

Abstract

Abstract A library of chiral supramolecular ligands, named BenzaPhos, of straightforward preparation (two steps from commercially or readily available starting materials) and modular structure, was designed and synthesized. The ligands were screened in the search for new rhodium catalysts for the enantioselective hydrogenation of several benchmark and industrially relevant substrates. Once a series of hits were identified, structural ...