Synthesis of [1, 3, NH2??15N3](5′ S)??8, 5′??cyclo??2′??deoxyguanosine

CK Malik, RS Das, AK Basu

文献索引：Malik, Chanchal K.; Das, Rajat S.; Basu, Ashis K. Journal of Labelled Compounds and Radiopharmaceuticals, 2013 , vol. 56, # 8 p. 376 - 381

全文：HTML全文

被引用次数: 0

摘要

To facilitate NMR studies and low-level detection in biological samples by mass spectrometry,[1, 3, NH2-15N3](5 0S)-8, 5 0-cyclo-2 0-deoxyguanosine was synthesized from imidazole-4, 5-dicarboxylic acid in 21 steps. The three 15N isotopes were introduced during the chemo-enzymatic preparation of [1, 3, NH2-15N3]-2 0-deoxyguanosine using an established procedure. The 15N-labeled 2 0-deoxyguanosine was converted to a 5 0- ...