Synthesis of [1, 3, NH2??15N3](5′ S)??8, 5′??cyclo??2′??deoxyguanosine

CK Malik, RS Das, AK Basu

Index: Malik, Chanchal K.; Das, Rajat S.; Basu, Ashis K. Journal of Labelled Compounds and Radiopharmaceuticals, 2013 , vol. 56, # 8 p. 376 - 381

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Abstract

To facilitate NMR studies and low-level detection in biological samples by mass spectrometry,[1, 3, NH2-15N3](5 0S)-8, 5 0-cyclo-2 0-deoxyguanosine was synthesized from imidazole-4, 5-dicarboxylic acid in 21 steps. The three 15N isotopes were introduced during the chemo-enzymatic preparation of [1, 3, NH2-15N3]-2 0-deoxyguanosine using an established procedure. The 15N-labeled 2 0-deoxyguanosine was converted to a 5 0- ...