Synthesis and antiproliferative activity of some variously substituted acridineand azacridine derivatives

…, C Marzano, G Chiarelotto, F Baccichetti…

文献索引：Ferlin, Maria Grazia; Marzano, Cristina; Chiarelotto, Gianfranco; Baccichetti, Francarosa; Bordin, Franco European Journal of Medicinal Chemistry, 2000 , vol. 35, # 9 p. 827 - 837

全文：HTML全文

被引用次数: 37

摘要

A group of 9-substituted acridine and azacridine derivatives (m-AMSA analogues) were synthesised following classical procedures as potential antitumour agents with inhibitory effects on DNA topoisomerase II. Some were found to have noticeable cytotoxicity against human HL-60 and HeLa cells grown in culture. Their non-covalent interactions with calf thymus DNA have been studied using fluorescence quenching. We evaluated DNA ...