Synthesis and antiproliferative activity of some variously substituted acridineand azacridine derivatives

…, C Marzano, G Chiarelotto, F Baccichetti…

Index: Ferlin, Maria Grazia; Marzano, Cristina; Chiarelotto, Gianfranco; Baccichetti, Francarosa; Bordin, Franco European Journal of Medicinal Chemistry, 2000 , vol. 35, # 9 p. 827 - 837

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Citation Number: 37

Abstract

A group of 9-substituted acridine and azacridine derivatives (m-AMSA analogues) were synthesised following classical procedures as potential antitumour agents with inhibitory effects on DNA topoisomerase II. Some were found to have noticeable cytotoxicity against human HL-60 and HeLa cells grown in culture. Their non-covalent interactions with calf thymus DNA have been studied using fluorescence quenching. We evaluated DNA ...