Imidazo [1, 2-a] quinoxalin-4-amines: A novel class of nonxanthine A 1-adenosine receptor antagonists

S Ceccarelli, A D'Alessandro, M Prinzivalli…

文献索引：Ceccarelli, Stefano; D'Alessandro, Alessandra; Prinzivalli, Michela; Zanarella, Sergio European Journal of Medicinal Chemistry, 1998 , vol. 33, # 12 p. 943 - 955

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被引用次数: 31

摘要

The syntheses and A1 adenosine receptor affinities of a number of imidazo [1, 2-a] quinoxalin-4-amines are reported. Structure—activity relationships within the series and in comparison with other similar tricyclic nonxanthine adenosine antagonists are discussed, leading to a putative common binding mode of these nitrogen-containing heterocycles to A1 adenosine receptors. Secondary amino compounds displayed the best affinities toward ...